Name: CHUNG, Sum Man Stephen
Position: Professor, Food Science and Technology; Dean of DST
Email: smchung@uic.edu.hk
Office:
T3-602-R23

Academic & Professional Qualifications
  • Ph.D. Molecular Biology (U. of California, Berkeley)
  • B.Sc. Biology (U. of Oregon, Eugene)
Research Areas
  • Mechanism of diabetic complications. Diabetes is a major health concern in China and other parts of the world. We are trying to understand why high blood glucose leads to secondary diseases such as cataract, retinopathy, neuropathy, nephropathy, and cardiovascular dysfunction. In the past we showed that polyol pathway plays a major role in these diseases. Currently we are investigating the role of mitochondrial dysfunction in the pathogenesis of these diseases.
  • Polyol pathway in cancer. We found that a large percentage of cancer overexpress aldose reductase and a related enzyme called ARL-1. We are investigating the role of this enzyme in the development of cancer and plan to take advantage of this phenomenon to develop drugs to treat cancer.
Selected Publications
  1. A.Y.W. Lee, S.K. Chung and S.S.M. Chung (1995) Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens. Proc. Natl. Acad. Sci. USA 92:2780-84.
  2. B.C.B. Ko, K.S.L. Lam, N.M.S. Wat, and S.S.M. Chung. (1995) An (AC)n dinucleotide repeat polymorphism marker at the 5' end of the aldose reductase gene is associated with early onset diabetic retinopathy in NIDDM patients. Diabetes 44:727-32.
  3. B.C.B. Ko, B. Ruepp, K. Bohren, K.M. Gabbay, and S.S.M. Chung. (1997) Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene. J. Biol. Chem. 272:16431-16437.
  4. D.L. Cao, S.T. Fan, and S.S.M. Chung (1998) Identification and characterization of a novel human aldose reductase-like gene. J. Biol. Chem. 273:11429-11435.
  5. A.Y.W. Lee and S.S.M. Chung. (1999) Contributions of polyol pathway to oxidative stress in diabetic cataract. FASEB J., 13:23-30.
  6. H.T.B. Ho, S.K. Chung, J.W.S. Law, B.C.B. Ko, S.C.F. Tam, H.L. Brooks, M.A. Knepper, and S.S.M. Chung. (2000) Aldose reductase deficient mice develop nephrogenic diabetes insipidus. Molec. Cell. Biol. 20:5840-46.
  7. B.C.B. Ko, A.K.L. Lam, A. Kapas, S.K. Chung, S.S.M. Chung. (2002) Fyn and p38 signaling are both required for maximum hypertonic activation of TonEBP/OREBP J. Biol. Chem. 277:46085-92.
  8. A.K.M. Lam, B.C.B. Ko, S. Tam, R. Morris, J.Y. Yang, S.K. Chung, and S.S.M. Chung (2004) Osmotic response element binding protein (OREBP) is an essential regulator of urine concentrating mechanism. J. Biol. Chem 279:48048-54.
  9. W.H. Tang, G.M. Kravtsov, M. Sauert, X.Y. Tong, X.Y. Hou, T.M. Wong, S.K. Chung, S.S.M. Chung. Polyol pathway impairs the Function of SERCA and RyR in ischemic-reperfused rat hearts by increasing oxidative modifications of these proteins. J. Molec Cellul Cardiol 2010 Jul;49(1):58-69.
  10. W.H. Tang, W.T. Cheng, G.M. Kravtsov, X.Y. Tong, X.Y. Hou, S.K. Chung, S.S.M. Chung Cardiac Contractile Dysfunction during Acute Hyperglycemia Due to Impairment of SERCA by Polyol Pathway Mediated Oxidative Stress. Am J Phy Cell Phy 2010 Sep;299(3):C643-53.
Awards
  • Chicago Community Trust Young Faculty Award (1982)
  • Senju Cataract Research Award (1997)
  • Outstanding Research Award, University of Hong Kong (1998)
Courses Taught at UIC
  • Applied Ethics
  • General Biology